The Bacillus coagulans, which has rapidly become popular due to the bacteriostatic effect, has become a new generation of probiotic health care products in the international market. Its annual sales have reached 500 million to 600 million US dollars. In contrast, China's R&D of this product is still in a slow phase. In this regard, the country should provide appropriate policy guidance to accelerate the pace of industrialization of Bacillus coagulation health products.
In recent years, a new type of health product, "Bacillus coagulans," which sounds very bizarre, has been quietly popularized in developed markets such as Europe, America and Japan, and has begun to become popular around the world at an unprecedented rate. Although the international microbiological community is still controversial about whether or not Bacillus coagulans belongs to the “Lactobacillus†family, as it has been found that any Lactobacillus found will not form spores, Bacillus coagulans not only produces lactic acid but also forms spores. . However, the dispute has been controversial. The current fact is that there are many kinds of health care products with Bacillus coagulans as the main component in the markets of developed countries. This type of product is not only expensive, it is at least 1 to 2 times more expensive than other probiotic health products, and it has a good market.
Japanese development is at the forefront
Due to the advertising effect of the mass media, probiotic health products have long been the hot selling products in the international medicine and health care products market in the 20th century. There are at least hundreds of different brands of probiotic health products on the US market alone (the United States sells them in the name of “dietary supplementsâ€, while in China, these products are mostly pharmaceuticals).
Japan is the world’s first developed country to study intestinal foods (probiotics). At present, there are as many as 100 kinds of probiotics such as bifidobacteria and lactic acid bacteria in the Japanese market. Annual sales exceed hundreds of billions of yen. Experts estimate that the total sales of global probiotic health products (including yoghurt products sold in Western markets) are about billions of US dollars or more. A large number of scientific studies have shown that Bifidobacterium is considered as one of the “longevity elementsâ€. The most telling problem is that in the world-famous longevity areas in the Transcaucasia, Chilean mountainous regions, and China's Guangxi Bama Autonomous County, a large number of bifidobacteria are found in the gut of the local elderly. Through years of research, the important health care value of probiotics to the human body has long been recognized by the international nutrition and health sciences community.
Since the 1990s, Japanese manufacturers have developed and marketed a number of new probiotic health products based on Bacillus coagulans. Among them, Three Lac is the earliest listed product with the highest market popularity. The product consists of three kinds of live probiotics: coagulation Bacillus, Bifidobacterium and Streptococcus faecalis contain more than 200 million Bacillus coagulans per capsule. ThreeLac has not only been listed in Japan but also entered the US and European markets in July 2002. According to the manufacturer, the product not only has intestinal health effects, it can also prevent women's fungal vaginitis, migraine, depression, heartburn, indigestion, chronic enteritis, acne and dysmenorrhea and other common diseases. A new type of health care product that treats diseases. When ThreeLac was launched in Japan, it gained the trust of consumers because it had no adverse side effects of chemical drugs and could be taken long-term.
It is understood that the price of ThreeLac in the Japanese market is 50,000 to 60,000 yen per box (60 small bags); the retail price in the US market is US$65 per box. The total sales of this product in Asia, such as Japan, South Korea, Singapore and China's Hong Kong and Taiwan regions, exceeded USD 53 million in 2001. By 2005, it had surpassed 100 million U.S. dollars. In just a few years, its sales volume has more than doubled. This shows that the Bacillus coagulans preparation is very popular in the market.
International market is hot
Because Bacillus coagulans has good heat resistance and is not afraid of gastric acid and digestive enzyme destruction, it is a raw material strain of a new generation of probiotics that has rapidly emerged in international intestinal health foods and has become a sought-after target for many Western health care products companies. . The human health effects of Bacillus coagulans include: improving the effective utilization of dietary fiber in the digestive tract, preventing excessive absorption of fat molecules (lipid reducing effect); reducing the risk of coronary heart disease; anti-constipation; prevention of Salmonella, rotavirus, deputy The diarrhea caused by pathogenic microorganisms such as Vibrio hemolyticus and other probiotics can greatly improve the human intestinal health and prevent fungal/yeast infections.
At present, a variety of health products containing Bacillus coagulans have been marketed overseas. Including: Nature's Plus (consisting of Bacillus coagulans + polysaccharides), Tancos (consisting of Bacillus coagulans + royal jelly), Pit-Stop (chocolate confections, Bacillus coagulans, anti-allergic), Fresh Start Bolus (a health drink produced by Nestlé in Switzerland containing Bacillus coagulans), GutFlora (VSL-3) (an oral capsule containing Bacillus coagulans), etc.
It has been estimated that due to the effect of preventing Candida infection, the global sales of Bacillus coagulans will rise to 500 million to 600 million U.S. dollars or more in the next few years. Medical researchers believe that about 70% of people have Candida parasites in their mouths, intestines, or vagina. They usually do not pose a hazard to the human body. Once the body's resistance declines, Candida will multiply and cause candidiasis. Such as thrush, fungal vaginitis, etc.). The use of conventional antifungal agents for the treatment of candidiasis is often unsatisfactory, whereas the administration of Bacillus coagulans increases the amount of lactic acid produced in the body, thereby effectively suppressing the overproduction of many pathogenic microorganisms, including Candida. Play the miraculous effect of "using bacteria to make bacteria." So far, there have been millions of patients with fungal vaginitis, including European, American, Japanese, and Hong Kong and Taiwan regions, who have taken Bacillus coagulation preparation health products. Most of the patients' fungal infections have been effectively controlled.
As early as 20 years ago, China began to develop domestically produced probiotics. Among them, the products with the earliest IPO, the largest domestic influence, and the highest market popularity are the first to promote "Three Oral Liquids", "Pefikang" and several other similar products. However, due to insufficient investment in advertising costs in China and little publicity in education and education, the Chinese have not yet fully realized the important health-care effects of probiotics on the human body.
Develop new uses
The medical community has discovered that another new use of Bacillus coagulans is to replace antibiotics as "animal growth promoters" as feed additives.
According to foreign reports, the addition of a small amount of Bacillus coagulans to chicken feed or ornamental animal feed can improve the disease resistance of chickens or ornamental animals, prevent chicken rickets and other diseases caused by microorganisms, and increase the survival rate of chickens. In addition, experiments conducted by the United States and other countries have confirmed that the number of colonies of harmful microorganisms such as salmonella in chickens or eggs that are frequently consumed by chickens containing Bacillus coagulans is greatly reduced, thereby increasing the food safety level of poultry eggs. Large livestock such as cows and pigs are often fed with feed containing Bacillus coagulans, which can not only increase the utilization rate of cellulosic feed, but also prevent the disease of large livestock and shorten the storage time.
Bacillus coagulans can also replace antibiotics such as tetracycline hydrochloride, monensin and avermectin, which were widely used in the past, as “animal growth promotersâ€, so as to solve the problem of excessive antibiotic residues in livestock (avian) meat that has plagued the breeding industry for many years. problem.
A few years ago, China's Inner Mongolia University and the Chinese Academy of Agricultural Sciences jointly carried out experimental research on the use of "Bacillus coagulans as a feed additive for cattle" to obtain preliminary results. In the future, low-cost Bacillus coagulans produced by the fermentation process is expected to be used on a large scale in the livestock industry as an alternative to antibiotics.
In contrast, various intestinal health products currently sold, such as bifidobacteria, lactic acid bacteria, and streptococcus faecalis, are very delicate. Once they encounter gastric acid and digestive enzymes, they will fail and they will be able to successfully enter the "preservation" of the intestinal tract. The number of bacteria is too small, so scholars at home and abroad have always been skeptical about the effectiveness of oral bifidobacteria. The spores can resist the corrosion of strong acids, so the benefits of Bacillus coagulans as a new generation of intestinal health products are not comparable to the previously listed probiotic health products.
It is reported that so far, Chinese companies have not yet developed listed Bacillus coagulant health foods. Compared with developed countries, the development and utilization of Bacillus coagulans is still in its infancy.
To sum up, the development of the second generation of new probiotic products - Bacillus coagulans - has a very broad market prospect. It is recommended that relevant domestic departments include it in the national key development projects to benefit the national economy and people's livelihood.
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Past life of Bacillus coagulans
Bacillus coagulation in the end what things? How can it become the best-selling health food ingredient in the international market in the 21st century? To understand its mysteries, we must first introduce the discovery process of the microorganism.
As early as the 1930s, when Western food industry industry was processing canned tomato sauce (ie, tomato sauce), which was in great demand, it was discovered that canned tomato sauce processed by conventional sterilization process became taste in a short period of time. Extremely acid, thus losing food value. Scientists from Austria and Switzerland in their respective laboratories analyzed acid somatosauce samples and found that a large number of spore-like microorganisms with decidua were detected. He was later identified by the famous Austrian bacteriologist Professor Horowitz Varshaven and Professor Novoteiro as a new type of microorganism. Because it can produce lactic acid and lectin, it was formally named "condensed spores." "Bacillus coagulans" (Latin name: Bacillus coagulans), and it is classified as a large family of lactic acid bacteria.
European microbiologists concluded that the reason why canned tomato sauce becomes sour is that its main cause is contamination with Bacillus coagulans. As the microorganism can withstand the high temperature during sterilization, it immediately revives after the product cools and reproduces in large quantities, converting the sugar in tomato sauce into lactic acid, which causes the product to become acid and inedible.
Bacillus coagulans, originally a harmful microorganism belonging to the food processing industry, turned into a new type of health food raw material more than half a century later, thanks to the best-selling world market for "probiotic" health products in the 1980s and 1990s. Because the probiotic strains used in the 20th century were mainly Bifidobacteria, Lactobacillus, and Streptococcus faecalis, these bacteria are very delicate and not high-temperature resistant. The biggest difference between Bacillus coagulans and the aforementioned microorganisms is that it is resistant to high temperatures and energy. Living in harsh environments such as strong acids or alkalis. Scientific research shows that Bacillus coagulans grows well in the intestines of humans or animals and can fully convert the carbohydrates in food into D-type or DL-type lactic acid, and these lactic acids can effectively kill or inhibit the intestinal tract. Harmful microorganisms. Compared with probiotics such as bifidobacteria and lactic acid bacteria that have been on the market for 30 years, Bacillus coagulans can successfully pass through the double gate of stomach acid and digestive enzymes and enter the intestine to “settle†after oral administration. Where they can quickly recover, become a living bacteria again, and begin to play its role in intestinal health. (Su Kui)
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